Synopsis of Sweet! Mouse Models of Diabetic Kidney Disease
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منابع مشابه
Sweet debate: fructose versus glucose in diabetic kidney disease.
The prevalence of diabetes continues to increase worldwide.1 Renal disease shows the strongest correlationwith excess mortality in diabetes, yet the mechanisms of diabetic kidney disease (DKD) remain poorly understood. It has been repeatedly demonstrated that hyperglycemia plays a crucial role in DKD initiation, both in patients and in animal models. Cells that are unable to downregulate their ...
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nents, can lead to de novo ESRD in subjects without identifiable ESRD risks. These data also increase the urgency to identify kidney toxic dietary components and if these components can promote ESRD even in subjects who have no identifiable risk factors. Diet remains a relatively underused component of the clinician’s armamentarium in the fight to prevent patients with CKD progressing to ESRD a...
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Animal models are essential tools to understand the mechanisms underlying the development and progression of renal disease and to study potential therapeutic approaches. Recently, interventional models suitable to induce acute and chronic kidney disease in the mouse have become a focus of interest due to the wide availability of genetically engineered mouse lines. These models differ by their d...
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Currently available rodent models exhibit characteristics of early diabetic nephropathy (DN) such as hyperfiltration, mesangial expansion, and albuminuria yet features of late DN (hypertension, GFR decline, tubulointerstitial fibrosis) are absent or require a significant time investment for full phenotype development. Accordingly, the aim of the present study was to develop a mouse model of adv...
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Introduction: The constantly increasing incidence of type 2 diabetes, probably due to obesity and sedentary life, has led to the increased incidence of macro- and microvascular diabetic complications such as nephropathy. Despite the prompt efforts to develop effective treatments for diabetes and slow the progression of its complications, it is still reported as the most common cause of chronic ...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 2018
ISSN: 0192-6233,1533-1601
DOI: 10.1177/0192623318799995